We study gynecologic diseases to understand their fundamental biology and translate discoveries into better prevention, detection, and treatment.
High-grade serous disease responds to first-line chemotherapy, only to return with resistance. Immunotherapies that transformed other cancers have barely moved the needle here. We study why treatments fail and develop new therapeutic strategies.
Affects 1 in 10 women, causing pain, infertility, and 7–10 years of diagnostic delay. Advanced lesions carry up to a 10-fold elevated risk of ovarian cancer. We're applying the tools that transformed cancer research to close this gap.
We integrate experimental and computational methods to understand disease at unprecedented resolution.
We profile individual cells to reveal hidden diversity and cell states, and we map how those cells are organized in tissue. scRNA-seq, snPATHO-seq, and Xenium.
We build organoid and primary cell models from patient samples. These systems reflect human biology and let us test findings and therapeutics.
Cell-state inference, spatial neighborhood analysis, trajectory modeling, and integration across modalities.
Our research is powered by patient-contributed samples and clinical data, grounding every project in human biology from the start.