Research

We study gynecologic diseases to understand their fundamental biology and translate discoveries into better prevention, detection, and treatment.

H&E-stained section of high-grade serous ovarian cancer

Ovarian cancer

The most lethal gynecologic malignancy.

High-grade serous disease responds to first-line chemotherapy, only to return with resistance. Immunotherapies that transformed treatment in other cancers have had little benefit in ovarian cancer. We study why treatments fail and develop new therapeutic strategies.

  • Why do high-grade serous ovarian cancers become resistant to chemotherapy after a strong initial response?

    Treatment resistance

  • How does the biology of rare ovarian cancer subtypes differ from high-grade serous disease?

    Rare subtypes

  • Why have immunotherapies failed in ovarian cancer?

    Novel immunotherapies

More info soon

H&E-stained endometriotic lesion: two glands in fibrotic stroma

Endometriosis

Chronic, under-studied, high-impact.

Affects 1 in 10 women, causing pain, infertility, and 7–10 years of diagnostic delay. Advanced lesions carry up to a 10-fold elevated risk of ovarian cancer. We're applying the tools that transformed cancer research to close this gap.

  • Can we detect endometriosis earlier?

    Early detection

  • Can developments in cancer therapeutics improve outcomes for women with endometriosis?

    Novel immunotherapies

  • How does endometriosis develop into ovarian cancer?

    Progression

More info soon

Our approach

We integrate experimental and computational methods to understand disease at unprecedented resolution.

Single-cell & spatial genomics

We profile individual cells to reveal hidden diversity and cell states, and we map how those cells are organized in tissue. scRNA-seq, snPATHO-seq, and Xenium.

Patient-derived disease models

We build organoid and primary cell models from patient samples. These systems reflect human biology and let us test findings and therapeutics.

Computational biology

Cell-state inference, spatial neighborhood analysis, trajectory modeling, and integration across modalities.

Ottawa GynePath Biobank

Our research is powered by patient-contributed samples and clinical data, grounding every project in human biology from the start.

More info soon